The Vita reminds me of the PSP go layout, which I have had some experience with as my other PSP. And believe me, if this thing is thinner and using small buttons, which it looks like it does, it's probably going to be an uncomfortable mess for men.
The PSP was big for a portable, but it felt comfortable to hold, and I never had trouble putting it in a case then in my pants pocket. The PSP Go is just way too small and makes your hands feel cramped after even just a short use. I hope they didn't go the same direction for the PSV, but it kinda looks like they did since it has the same basic shape and button size. Also the triggers were a bitch to hit on the Go, but that was because they were so thin and that damn screen practically sat on them.
Only other complaint I had about the PSPs was the fact they should have had some way to protect the screen. I think flip designs should be a standard as it helps protect the screen from scratches and dirt, which my PSP 2000 has a lot of. Or maybe just a way to flip the screen part like you can with some cd players in cars.